Renal tubular epithelial cells: the neglected mediator of ... - Nature
Nov 13, 2018 · Autophagy exerts bidirectional effects on TECs upon injury. Autophagy is a mechanism that engulfs unnecessary or dysfunctional cellular components and can help TECs adapt to a variety of...
The Emerging Role of Renal Tubular Epithelial Cells in the ...
This review summarizes recent advances in our understanding of renal tubular epithelial cells in LN, the potential role of tubular epithelial cells as biomarkers in the diagnosis, prognosis, and treatment of LN, and the future therapeutic potential of targeting the tubulointerstitium for the treatment of patients with LN.
Renal tubular epithelial cells: the neglected mediator of ...
Abstract. Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide. For a long time, interests in renal fibrosis have been concentrated on fibroblasts and myofibroblasts.
Renal proximal tubular epithelial cells: review of isolation
Nov 20, 2020 · In this review we will focus on human proximal tubular epithelial cells. We will cover human kidney culture models, cell sources, isolation, culture, immortalization, and characterization subdivided into morphological, phenotypical, and functional characterization.
Cellular senescence of renal tubular epithelial cells in acute …
Feb 5, 2024 · The senescence of renal tubular epithelial cells (RTEC) constitutes a critical cellular event in the progression of acute kidney injury (AKI). RTEC senescence inhibits renal...
Chromatin accessibility dynamics dictate renal tubular epithelial cell ...
Nov 28, 2022 · Renal tubular epithelial cells (TECs) can initiate an adaptive response to completely recover from mild acute kidney injury (AKI), whereas severe injury often leads to persistence of maladaptive...
Renal tubular epithelial cells response to injury in acute kidney ...
Sep 1, 2024 · The renal tubular epithelial cells (TECs) represent the central cell type affected by AKI, and their notable regenerative capacity is critical for the recovery of renal function in afflicted patients. The adaptive repair process initiated by surviving …
Renal proximal tubular epithelial cells: review of isolation
Nov 10, 2020 · HK-2 cells have some renal characteristics such as brush border enzymatic activity (i.e. activity related to alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT), LAP and are positive for proximal tubular epithelial marker APN, as well as show some functional characteristics (Na + dependent glucose transport, adenylate cyclase ...
Renal tubular epithelial cells: the neglected mediator of ... - PubMed
Nov 13, 2018 · TECs, rather than a victim or bystander, are probably a neglected mediator in renal fibrosis, responding to a variety of injuries. The maladaptive repair mechanisms of TECs may be the key point in this process. In this review, we will focus on the role of TECs in tubulointerstitial fibrosis.
Renal tubular epithelial cells: the neglected mediator of ...
Nov 13, 2018 · For a long time, interests have focused on fibroblasts and myofibroblasts. However, in recent years, a growing number of studies are shedding light on the role of tubular epithelial cells (TECs) in renal fibrosis 4.