Negative feedback control of neuronal activity by microglia
2020年9月30日 · Microglia, the brain’s resident macrophages, help to regulate brain function by removing dying neurons, pruning non-functional synapses, and producing ligands that support neuronal survival 1....
Microglia rescue neurons from aggregate-induced neuronal …
2024年7月25日 · This article reports that microglia use tunneling nanotubes (TNTs) to extract toxic aggregates of alpha-synuclein (α-syn) and tau from neurons, and donate healthy mitochondria to them. The study also shows that TNT-mediated aggregate transfer is compromised in microglia with some gene variants associated with neurodegenerative diseases.
Microglia in neurodegenerative diseases: mechanism and …
2023年9月22日 · Here we comprehensively review the biology of microglia and the roles of microglia in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, multiple system atrophy ...
Microglia monitor and protect neuronal function through …
Mechanisms underlying microglia–neuron communication remain elusive. Here, we identified an interaction site between neuronal cell bodies and microglial processes in mouse and human brain. Somatic microglia–neuron junctions have a specialized nanoarchitecture optimized for …
Neurons shape the identity of microglia in the brain - Nature
2022年8月10日 · Neurons shape the identity of microglia in the brain. Microglia are immune cells that regulate the function and activity of the nervous system. Detailed molecular and spatial...
Microglia-neuron crosstalk: Signaling mechanism and control of …
2019年10月1日 · The alteration of neuron-microglia communication contributes to brain disease states with consequences, ranging from synaptic function to neuronal survival. This review focuses on the signaling pathways responsible for neuron-microglia crosstalk, highlighting their physiological roles and their alteration or specific involvement in disease.
New Insights into Microglia-Neuron Interactions: A Neuron's ... - PubMed
2019年5月1日 · In this review, we briefly summarize the known physiological roles of microglia-neuron interactions in brain homeostasis and attempt to outline some major directions and challenges of future microglia research.
How microglia sense and regulate neuronal activity - PubMed
In this review, we consider the extracellular molecules, receptors, and mechanisms that allow microglia to sense neuronal activity changes under both hypoactivity and hyperactivity. We also highlight emerging in vivo evidence that microglia regulate neuronal activity, ranging from physiological to pathophysiological conditions.
Current perspectives on microglia-neuron communication in the …
2024年1月7日 · Microglia regulate key neuronal functions such as synaptic pruning and neurogenesis. •. Indirect microglia-neuron interaction may via intermediate organs, cells, or factors. •. Direct interaction is a compartment-dependent membrane-membrane contact. •. Understanding these signals provides insights into fundamental brain mechanisms. Abstract.
Microglia-neuron crosstalk: Signaling mechanism and control of …
2019年10月1日 · The alteration of neuron-microglia communication contributes to brain disease states with consequences, ranging from synaptic function to neuronal survival. This review focuses on the signaling pathways responsible for neuron-microglia crosstalk, highlighting their physiological roles and their alteration or specific involvement in disease.