Histone H4 - an overview | ScienceDirect Topics
Histone H4 is defined as one of the four core histones that make up the nucleosome, along with Histone H2A, H2B, and H3. It plays a crucial role in chromatin structure and gene regulation …
Externalized histone H4 orchestrates chronic inflammation by …
2019年5月1日 · Here we use mouse models of atherosclerosis—a major underlying cause of mortality worldwide—to demonstrate that extracellular histone H4-mediated membrane lysis of …
Genome protection: histone H4 and beyond - PMC - National …
2020年6月17日 · The histone H4 protein contains a core histone-fold domain and unstructured amino (N)- and carboxy (C)-terminal tails (Luger et al. 1997). To address the question of which …
The secret life of histones | Science - AAAS
2020年7月3日 · Histone proteins are the ubiquitous organizers of all eukaryotic genomes . Two each of the histones H2A, H2B, H3, and H4 form a disk-shaped assembly around which 147 …
Histone H4 lysine 16 acetylation controls central carbon ... - Nature
2021年10月27日 · MOF (also known as KAT8) is the major KAT responsible for acetylation of histone H4 at lysine 16 (H4K16ac), a unique histone mark that directly modulates higher-order …
Histone H4 - an overview | ScienceDirect Topics
Histone 4 is a 102–135 amino acid core protein with a structural motif known as histone fold. It forms a dimer with H3 and wraps around the DNA. Extracellular histones use Toll-like …
The roles of histone variants in fine-tuning chromatin ... - Nature
2020年7月14日 · All core histones in mammals exist as one or more such replication-independent variant counterparts, including the newly discovered Hominidae-specific histone H4 variant …
Histone H4 - an overview | ScienceDirect Topics
The histone H4 binds H3 and forms H3–H4 dimers that are later incorporated in the nucleosomal histone octamers. Apart from a human truncated C-terminal variant (i.e. H4G), all metazoans …
Genome protection: histone H4 and beyond | Current Genetics
2020年6月17日 · The histone H4 levels play an important role in maintaining genome stability via regulating homologous recombination, as reduced histone H4 dosage was found to be linked …
Externalized histone H4 orchestrates chronic inflammation by …
Here we use mouse models of atherosclerosis-a major underlying cause of mortality worldwide-to demonstrate that extracellular histone H4-mediated membrane lysis of smooth muscle cells …
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