CCL5-deficiency enhances intratumoral infiltration of CD8
2018年7月10日 · Here, we demonstrated that CCL5-deficiency delayed tumor growth and metastasis via facilitating CD8+ T cells to accumulate into tumor site in CRC mouse models.
Tumor-immune profiling of CT-26 and Colon 26 syngeneic mouse …
2021年11月13日 · CT-26 tumors are infiltrated with more anti-tumor immune cells than Colon 26 tumors. The presence of pre-existing lymphocytes and myeloid cells within the tumor is known to influence response to immune checkpoint inhibitors [3].
Interferon-γ in the tumor microenvironment promotes the
2024年3月13日 · In view of the reverse trend of CD8 expression in CT26-shB7H4 tumors detected by FC (Fig. 3I) and IHC (Fig. 3J), we analyzed two possible reasons: (1) The weak staining of CD8 and the...
SET facilitates immune escape of microsatellite stability colorectal ...
2024年10月17日 · IHC analysis of human MSS and MSI CRC samples revealed that patients with MSI CRC had higher levels of CD8+ T cell expression (Figure S4D). Collectively, these results reflect that high expression of SET is associated with a “cold” immune microenvironment via negatively regulated CD8 + T cell infiltration in MSS CRC.
Comparison of the molecular and cellular phenotypes of common …
2020年1月2日 · CT26, a colon tumor model, had the highest immunogenicity and was the model most responsive to CTLA4 inhibitor treatment, by contrast to the relatively low immunogenicity and response rate to checkpoint inhibitor therapies in human colon cancers.
A novel co-culture assay to assess anti-tumor CD8+ T cell …
2020年12月1日 · Our co-culture assay is therefore suitable as proof of principle for in vivo therapeutic studies testing immunotherapies, and specifically to assess the involvement of cytotoxic CD8 + T cells in treatment response in LLC and CT26 tumor models.
CXCL8 induces M2 macrophage polarization and inhibits CD8
2023年9月4日 · In this study, we present, for the first time, the correlation between tumor-derived CXCL8 and the infiltration of M2 macrophages in CRC, which can be potentiated by IL-1β in TME. Additionally, we elucidate the mechanism underlying the polarization of M2 macrophages through the CXCL8/STAT3 axis.
MAP7D2 reduces CD8 - Cell Press
2023年1月4日 · Consistently, the IHC staining results demonstrated that the infiltration of CD3 + T cells and CD8 + T cells was dramatically increased in MAP7D2 knockdown CT26 tumors treated with anti-PD-1 (Figures 4E and 4F).
Targeting G-quadruplex by TMPyP4 for inhibition of colorectal …
4 天之前 · This association was consistently observed in immunohistochemistry (IHC) analyses, confirming an augmented presence of CD8 + T cells in G4 high-expressing tumors (Fig. 1c).
Long-lasting mRNA-encoded interleukin-2 restores CD8
2024年4月8日 · (C) CD8 + T cell and NK cell infiltration in CT26 or MC38 WT and B2m −/− tumors determined by αCD8 immunohistochemistry (IHC) or immunofluorescence (IF) staining and Ncr1 in situ hybridization (ISH) 19 days after inoculation