Neonatal high-frequency oscillatory ventilation: where are we now?
High-frequency oscillatory ventilation (HFOV) is an established mode of respiratory support in the neonatal intensive care unit. Large clinical trial data is based on first intention use in preterm infants with acute respiratory distress syndrome. Clinical practice has evolved from this narrow population. HFOV is most often reserved for term and …
What’s new in the management of neonatal early-onset sepsis?
The expert guidelines highlighted in this review provide an evidence-based framework for approaching at-risk infants and allow for a more limited and standardised approach to antibiotic use. While these guidelines have significantly reduced antibiotic utilisation worldwide, optimally each unit would individualise their approach to early onset sepsis (EOS) based on the neonatal population they ...
Homepage | ADC Fetal & Neonatal Edition
2 天之前 · s an edition of ADC from BMJ and RCPCH, publishing perinatal & neonatal medicine research and reviews. Archives of Disease in Childhood: Fetal & Neonatal is a Plan S compliant Transformative Journal. Archives of Disease in Childhood is led by Dr Nick Brown, clinician, epidemiologist and international child health expert.
Supporting all breaths versus supporting some breaths during ...
Background National Institute for Health and Clinical Effectiveness (NICE), UK, guideline published in 2019 recommends the use of volume-targeted ventilation (VTV). It recommends synchronised intermittent mandatory ventilation (SIMV) over the modes that support-all-breaths, for example, assist control ventilation (ACV). We conducted a systematic review and meta-analysis of the studies ...
Management and investigation of neonatal encephalopathy: 2017 …
This review discusses an approach to determining the cause of neonatal encephalopathy, as well as current evidence on resuscitation and subsequent management of hypoxic-ischaemic encephalopathy (HIE). Encephalopathy in neonates can be due to varied aetiologies in addition to hypoxic-ischaemia. A combination of careful history, examination and the judicious use of investigations can help ...
a single CRP value for proven sepsis was 64% (95% CI 53 to. 59) with a positive predictive value of only 14% (95% CI 11 to. 17).45 However, if serial CRP values remain normal, there is a low likelihood of infection with a negative predictive value of nearly 100%46 The 2021 NICE guidelines recommend use of.
Understanding the principle biophysics concepts of pulmonary …
Pulmonary surfactant (PS) is a lipid-protein complex essential to stabilise the delicate structure of mammalian alveoli along with successive compression-expansion respiratory cycles. To do so, surfactant reduces dramatically surface tension at the air-liquid interface, an activity that depends critically on a proper lipid composition and the presence of some specific surfactant proteins. Lack ...
Nucleated red blood cells in the fetus and newborn
Normal newborn values. In 1924, Lippman 9 reported nRBCs in the blood of 41 of 42 newborns in the first day of life. These cells constituted about 500 nRBCs/mm 3 or 0.1% of the newborns' circulating red blood cells. Since then, many investigators have reported similar values at and shortly after birth (table 1).
Neonatal jaundice in infants born at 37 weeks: is NICE treating too ...
Neonatal jaundice affects approximately 60% of term and 80% of preterm infants within the first week of life. Gestation-based treatment threshold graphs by the National Institute of Health and Care Excellence are used to guide jaundice management in the UK.1 NICE treatment thresholds at 37-week gestation are much lower compared with ≥38 weeks and also when compared with the previous and ...
Management of severe alloimmune thrombocytopenia in the …
Neonatal alloimmune thrombocytopenia is the platelet homologue of haemolytic disease of the newborn and was initially thought to be a rare disease. However, a recent prospective screening study in 25 000 non-selected pregnant women showed an incidence of severe thrombocytopenia (< 50 × 10 9 platelets/litre) caused by anti-HPA-1a antibodies ...