How regulatory T cells work | Nature Reviews Immunology
Regulatory T (T Reg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial...
Regulatory T cells: Purpose, Function & Development - Cleveland Clinic
2022年7月13日 · Regulatory T cells, also called Tregs, are white blood cells that regulate your immune system response. Tregs control how your immune system reacts to unwelcome substances from outside and inside your body.
Regulatory T Cells (Tregs) | British Society for Immunology
As the name suggests regulatory T cells (also called Tregs) are T cells which have a role in regulating or suppressing other cells in the immune system. Tregs control the immune response to self and foreign particles ( antigens ) and help prevent autoimmune disease.
The regulation and differentiation of regulatory T cells and their ...
2024年2月19日 · The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central role in regulating immune responses provided a deeper understanding of self-tolerance.
How regulatory T cells work - PMC - PubMed Central (PMC)
Regulatory T (T reg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting anti-tumour immunity. Given that T reg cells can have both beneficial and deleterious effects ...
Principles of regulatory T cell function: Immunity - Cell Press
2023年2月14日 · Treg cells are an immunosuppressive lymphocyte subset essential for preventing autoimmunity. Dikiy and Rudensky review the mechanisms by which Treg cells prevent autoimmunity, mitigate inflammation, and support tissue function.
How do Regulatory T Cells Work? - PMC - PubMed Central (PMC)
CD4+ T cells are commonly divided into regulatory T (Treg) cells and conventional T helper (Th) cells. Th cells control adaptive immunity against pathogens and cancer by activating other effector immune cells.
Regulatory T Cells: Differentiation and Function - PMC
Regulatory T (Treg) cells expressing the X chromosome–linked transcription factor Foxp3 suppress inflammatory responses in diverse biological settings and serve as a vital mechanism of negative regulation of immune-mediated inflammation. Introduction.
Regulatory T cells in autoimmune disease | Nature Immunology
2018年6月20日 · This Review summarizes the newer concepts of Treg cell instability, Treg cell plasticity and tissue-specific Treg cells, and their relationship to autoimmunity.
Systems immunology of regulatory T cells: can one circuit explain …
2023年9月8日 · Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular circuits involving Tregs and other cell types across space and time.
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