Targeting integrin pathways: mechanisms and advances in …
Jan 2, 2023 · RGD-binding integrins. RGD-binding integrins refer to a class of integrins that bind with the tripeptide motif Arg–Gly–Asp in ECM proteins, including αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 ...
Arginylglycylaspartic acid - Wikipedia
Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans. Cell adhesion proteins called integrins recognize and bind to this sequence, which is found within many matrix proteins, including fibronectin, fibrinogen ...
RGD-Binding Integrins Revisited: How Recently Discovered
Apr 4, 2021 · The present review comprehensively analyzes the state-of-the-art knowledge on the roles of RGD-binding integrin subtypes in cancer and non-cancerous diseases and outlines the latest achievements in the design and development of synthetic ligands and their application in biomedical, translational, and molecular imaging approaches.
Structure–Activity Relationships of RGD-Containing Peptides in Integrin …
Jan 24, 2023 · The RGD motif is a cell adhesion sequence that binds to integrins, a receptor family for extracellular matrix proteins. We previously reported that the RGDX 1 X 2 sequence, where X 1 X 2 is VF or NY, is required for integrin αvβ5-mediated cell adhesion.
RGD-Binding Integrins Revisited: How Recently Discovered …
Apr 4, 2021 · In the present review, we summarize the latest discoveries in RGD-binding integrin (patho-) biology as well as progresses made in the design and application schemes of RGD-based integrin ligands for new and promising approaches in integrin-targeted therapy concepts.
De novo design of highly selective miniprotein inhibitors of …
Sep 13, 2023 · The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance.
Exploring the Role of RGD-Recognizing Integrins in Cancer
Sep 4, 2017 · Eight members of the integrin superfamily recognize the tripeptide motif Arg-Gly-Asp (RGD) within extracelluar matrix (ECM) proteins. These integrins constitute an important subfamily and play a major role in cancer progression …
A Comprehensive Evaluation of the Activity and Selectivity Profile of ...
Jan 11, 2017 · Linear RGD integrin inhibitory peptides. The RGD-sequence was originally discovered as the minimal binding epitope of fibronectin and has extensively been investigated over the last decades.
RGD and other recognition sequences for integrins - PubMed
The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands.
Molecular View on the - ACS Publications
Oct 3, 2023 · Therefore, we conjugated Fc to five synthetic, Arg-Gly-Asp (RGD)-based integrin binding ligands to enable targeting of the cell adhesion and signaling receptor integrin subtypes αvβ3, α5β1, or αvβ6, which are overexpressed in various, distinct tumors.
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