Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins
2021年12月9日 · P27/kip1 belongs to the cell cycle control protein Cip/Kip family and is a negative cell cycle regulator. The continuous phosphorylation and ubiquitination-associated degradation of P27 promote the cell cycle to cross the G0/G1 checkpoint, thereby avoiding programmed cell death due to virus infection ( 13 , 17 ).
The poxvirus F17 protein counteracts mitochondrially ... - Nature
2023年11月30日 · Mitochondrial hyperfusion coordinates mtDNA release and increased glycolysis to fuel antiviral responses in the absence of F17. Recent studies have shown that some viruses cause mitochondrial ...
Structure of the poxvirus core - Nature Structural & Molecular …
2024年6月18日 · Poxviruses range from deadly smallpox to attenuated vaccinia virus used in vaccines and oncolytic vectors. Despite their broad, if antithetical, effects on humankind, the mechanistic details...
Poxvirus tropism - Nature Reviews Microbiology
This review summarizes our current understanding of poxvirus tropism and host range, and discusses the prospects of exploiting host-restricted poxvirus vectors for vaccines, gene therapy or...
Poxviruses and the Evolution of Host Range and Virulence
The successful replication of poxviruses depends on their effective manipulation of the host antiviral responses, at the cellular-, tissue- and species-specific levels, which constitutes a molecular basis for differences in poxvirus host range and virulence.
Assembly and Evolution of Poxviruses - PubMed
The assembly progresses through five major stages-endoplasmic reticulum (ER) membrane alteration and rupture, crescent formation, immature virion formation, genome encapsidation, virion maturation and in a subset of viruses, additional envelopment of the …
Poxvirus host cell entry - PubMed
Poxviruses are characterized by their large size, complex composition, and cytoplasmic life cycle. They produce two types of infectious particles: mature virions (MVs) and extracellular virions (EVs). Both MVs and EVs of vaccinia virus, the model poxvirus, take advantage of host cell endocytosis for ….
Poxvirus under the eyes of electron microscope
2022年11月14日 · Zoonotic poxvirus infections pose significant threat to human health as we have witnessed recent spread of monkeypox. Therefore, insights into molecular mechanism behind poxvirus replication cycle are needed for the development of efficient antiviral strategies.
Cytoplasmic factories, virus assembly, and DNA replication …
2020年1月16日 · Poxviruses replicate in cytoplasmic structures called factories and each factory begins as a single infecting particle. Sixty-years ago Cairns predicted that this might have effects on vaccinia virus (VACV) recombination because the factories would have to collide and mix their contents to permit recombination.
Cell cycle deregulation by a poxvirus partial mimic of anaphase
2009年11月17日 · Expression of the viral protein led to cell cycle deregulation and the accumulation of APC substrates in a manner consistent with impaired APC function. Our data characterize this protein as a regulator of APC activity, and consequently, we have called it PACR (poxvirus APC/cyclosome regulator).