Morpholine as a privileged structure: A review on the medicinal ...
The morpholine ring is a versatile and readily accessible synthetic building block, it is easily introduced as an amine reagent or can be built according to a variety of available synthetic methodologies.
Morpholine as ubiquitous pharmacophore in medicinal chemistry: Deep ...
2020年3月1日 · The ability of morpholine to enhance the potency of the molecule through molecular interactions with the target protein (kinases) or to modulate the pharmacokinetic properties propelled medicinal chemists and researchers to synthesize morpholine ring by the efficient ways and to incorporate this moiety to develop various lead compounds with ...
Morpholine - NIST Chemistry WebBook
Morpholine. Formula: C 4 H 9 NO. Molecular weight: 87.1204. IUPAC Standard InChI:InChI=1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2 Copy. IUPAC Standard InChIKey:YNAVUWVOSKDBBP-UHFFFAOYSA-N Copy. CAS Registry Number: 110-91-8.
Morpholine As a Scaffold in Medicinal Chemistry: An Update on …
2020年2月4日 · An overview of the main approaches toward morpholine ring forming reactions or ring functionalization, is presented herein as one of the medicinal chemistry aspects of morpholine (bioactive) derivatives.
Occurrence of Morpholine in Central Nervous System Drug …
In CNS-active compounds, morpholines are used (1) to enhance the potency through molecular interactions, (2) to act as a scaffold directing the appendages in the correct position, and (3) to modulate pharmacokinetic/pharmacodynamic (PK/PD) properties.
Morpholine | C4H9NO | CID 8083 - PubChem
2016年1月13日 · Morpholine is an organic heteromonocyclic compound whose six-membered ring contains four carbon atoms and one nitrogen atom and one oxygen atom that lies opposite to each other; the parent compound of the morpholine family. It has a role as a NMR chemical shift reference compound.
Development of morpholine ring-bearing halogenated α,β …
2024年1月22日 · Collectively, nine halogenated chalcones bearing a morpholine ring were synthesized, and their inhibitory effects on MAOs were assessed. MHC5 and MHC4 are selective MAO-B inhibitors with reversible and competitive modes of inhibition.
Syntheses of 2- and 3-Substituted Morpholine Congeners via Ring …
2023年4月26日 · The present review primarily focused on discussing the most promising synthetic leads contg. morpholine ring along with structure-activity relationship (SAR) to reveal the active pharmacophores accountable for anticancer, anti-inflammatory, antiviral, anticonvulsant, antihyperlipidemic, antioxidant, antimicrobial and antileishmanial activity.
Ring-opening functionalizations of unstrained cyclic amines
2020年9月21日 · Here we report a highly efficient and practical strategy for the ring-opening functionalization of a wide variety of unstrained cyclic amines, including but not limited to 5- and 6-membered...
Morpholine - an overview | ScienceDirect Topics
Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a moiety of great significance. It forms an important intermediate in many industrial and organic syntheses. Morpholine containing drugs are of high therapeutic value.
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