Lipid peroxidation - Wikipedia
Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, [1] resulting in the formation of peroxide and hydroperoxide derivatives. [2] It occurs when free radicals , specifically reactive oxygen species (ROS), interact with lipids within cell membranes , typically polyunsaturated fatty ...
Lipid droplets and cellular lipid flux - Nature Cell Biology
2024年3月7日 · Abstract. Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we...
Analysis of Oxidized Lipids and Lipid Peroxidation in ...
2020年8月9日 · Oxidation of polyunsaturated (PUFA) lipids, catalyzed by free radicals either by non-enzymatic or enzymatic mechanisms, is highly critical in living cells during toxicity, pathophysiological events and disease states, radiation exposure, xenobiotic and drug metabolism, and aging.
Lipid Peroxidation and Antioxidant Protection - PMC - PubMed …
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins.
High cholesterol - Symptoms and causes - Mayo Clinic
2023年1月11日 · Overview. Cholesterol is a waxy substance found in your blood. Your body needs cholesterol to build healthy cells, but high levels of cholesterol can increase your risk of heart disease. With high cholesterol, you can develop fatty deposits in your blood vessels.
Lipid metabolism dysfunction induced by age-dependent ...
2022年5月25日 · Impaired Elovl2 function disturbs lipid synthesis with increased endoplasmic reticulum stress and mitochondrial dysfunction, leading to key aging phenotypes at both cellular and...
Lipid Peroxidation Drives Liquid–Liquid Phase Separation and …
2024年1月3日 · The peroxidation of membrane lipids by free radicals contributes to aging, numerous diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the structure and physicochemical properties of lipids, leading to bilayer thinning, altered fluidity, and increased permeability of membranes in model systems.
Lipids associated with autophagy: mechanisms and therapeutic …
2024年10月30日 · Autophagy is a molecular process essential for maintaining cellular homeostasis, with its impairment or dysregulation linked to the progression of various diseases in mammals. Specific lipids ...
Effect of Lipid Peroxidation on the Properties of Lipid Bilayers: …
2007年12月12日 · Lipid peroxidation plays an important role in cell membrane damage. We investigated the effect of lipid peroxidation on the properties of 1-palmitoyl-2-linoleoyl- sn -glycero-3-phosphatidylcholine (PLPC) lipid bilayers using molecular dynamics simulations.
Lipid peroxidation and tissue damage - PubMed
Since lipid peroxidation is a self-propagating chain-reaction, the initial oxidation of only a few lipid molecules can result in significant tissue damage. Despite extensive research in the field of lipid peroxidation it has not yet been precisely determined if it is the cause or an effect of several pathological conditions.
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