Targeting integrin pathways: mechanisms and advances in …
2023年1月2日 · Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in biochemical and...
Integrins: An Overview of Structural and Functional Aspects
Integrins are heterodimeric transmembrane receptors that mediate cell-adhesion. 1 With their extracellular head region, most integrins bind extracellular matrix (ECM) glycoproteins such as laminins and collagens in basement membranes or connective tissue components like fibronectin.
Integrin Receptor - an overview | ScienceDirect Topics
Integrin receptors are transmembrane adhesion proteins that connect the extracellular environment to the inside of cells. They play a crucial role in various cellular processes such as adhesion, migration, signaling, and survival, and are associated with pathological conditions including inflammation and fibrosis.
The role and regulation of integrins in cell migration and invasion
2024年9月30日 · Integrin receptors connect cells to the extracellular matrix, mediating cell interactions, adhesion and signalling. This Review discusses integrin function in cell migration, including...
The role of integrins in inflammation and angiogenesis
2020年10月7日 · Integrins are a family of ubiquitous αβ heterodimeric receptors that interact with numerous ligands in physiology and disease. Integrins play a key role in cell proliferation, tissue...
Integrin Structure, Activation, and Interactions - PMC
Integrin receptors possess two large extracellular “heads” that mediate ligand binding and subunit association. Two short intracellular “legs” assemble cytoplasmic signaling complexes and transmit structural changes to the heads during activation that allow them to bind ligand.
Integrin signalling and function in immune cells - PMC
Integrins are transmembrane adhesion receptors that mediate cell–cell and cell–extracellular matrix adhesion and also induce bidirectional signalling across the cell membrane to regulate cell proliferation, activation, migration and homeostasis. 1 Each integrin contains one α subunit and one β subunit. So far, eighteen α subunits and ...
Integrins - Cell Press
2002年9月20日 · Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions. In addition to mediating cell adhesion, integrins make transmembrane connections to the cytoskeleton and activate many intracellular signaling pathways.
Integrin adhesion complexes: Current Biology - Cell Press
2021年5月24日 · Integrins are heterodimeric cell-surface receptors composed of a larger α subunit and a smaller β subunit. There are 18 α and 8 β subunits in mammals that give rise to 24 distinct αβ integrin pairs.
Integrins - Molecular Biology of the Cell - NCBI Bookshelf
Integrins are the principal receptors used by animal cells to bind to the extracellular matrix. They are heterodimers and function as transmembrane linkers between the extracellular matrix and the actin cytoskeleton. A cell can regulate the adhesive activity of its integrins from within.
- 某些结果已被删除