Liver lipid metabolism - PubMed
The liver plays a key role in lipid metabolism. Depending on species it is, more or less, the hub of fatty acid synthesis and lipid circulation through lipoprotein synthesis. Eventually the accumulation of lipid droplets into the hepatocytes results in hepatic steatosis, which may develop as a …
The regulation of hepatic fatty acid synthesis and partitioning
2019年9月25日 · The liver is a key regulator of systemic lipid metabolism. It is connected to the gut by the hepatic portal vein, which provides the majority of the liver’s blood supply, with the hepatic...
Lipid and Lipoprotein Metabolism in Liver Disease - Endotext
2019年7月21日 · This chapter discusses the interplay between lipid metabolism and chronic liver diseases focusing on NAFLD, alcoholic liver disease, hepatitis C, hepatitis B, cholestatic liver disease, and cirrhosis.
An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver …
The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, ...
Regulation of Hepatic Metabolism, Recent Advances, and Future ...
Mechanistically, the hormonal regulation of hepatic metabolism includes allosteric activation/inhibition, changes in metabolic fluxes and transcriptional regulation of key gluconeogenic/lipogenic components to support long-term activity of these pathways [6, 4, 7, 8].
Lipid metabolism in the liver - Nature
2023年9月13日 · This collection covers all aspects of hepatic lipid metabolism, from discovery projects to translational and clinical aspects of hepatic diseases.
Metabolic-associated fatty liver disease and lipoprotein metabolism
2021年8月1日 · This review article discusses recent research addressing hepatic lipid synthesis, VLDL production, and lipoprotein internalization as well as the lipid exchange between adipose tissue and the liver in the context of MAFLD.
Autophagy and hepatic lipid metabolism: mechanistic insight …
2024年8月2日 · Autophagy, a cellular catabolic process, has emerged as a primary mechanism of lipid metabolism in mammalian hepatocytes. Furthermore, preclinical studies with autophagy modulators have shown...
The hepatic lipidome: From basic science to clinical translation
2020年1月1日 · Excessive lipid accumulation due to dysregulated lipid metabolism predisposes the liver to steatosis, cirrhosis, and hepatocellular carcinoma. Lipids are generally compartmentalized in specialized organelles called lipid droplets that enable cells to store and release lipids in a regulated manner.
Hepatic Lipid Metabolism - SpringerLink
2010年1月1日 · Regulation of Hepatic Lipogenesis. As de novo synthesis of fatty acids in liver is regulated by insulin and glucose, it is essential to understand their role in activating the membrane-bound lipogenic transcription factor SREBP-1c, an important member of SREBP family of transcription factors [109].
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