Pseudogout (Chondrocalcinosis or CPPD) - Cleveland Clinic
2024年5月28日 · The extra CPP forms small crystals that build up in the cartilage and fluid-filled synovial membranes cushioning your joints. Eventually, the CPP crystals clump together inside your joints and cause a flare of pseudogout symptoms.
Calcium Pyrophosphate Deposition Disease - StatPearls - NCBI Bookshelf
2023年6月20日 · Calcium pyrophosphate deposition disease (CPPD) is a crystal deposition arthropathy involving the synovial and periarticular tissues. Its clinical presentation may range from being asymptomatic to acute or chronic inflammatory arthritis.
Clinical manifestations and diagnosis of calcium pyrophosphate crystal …
2024年8月9日 · Precipitation of crystals of calcium pyrophosphate (CPP) in connective tissues may be associated with several clinical syndromes, but is sometimes asymptomatic. The consequences of CPP deposition include acute inflammatory arthritis, inflammatory and degenerative chronic arthropathies, and radiographic cartilage calcification and constitute the ...
Calcium Pyrophosphate Crystals: Causes, Risk Factors, and More
2023年11月19日 · While pyrophosphate is a naturally occurring chemical in the body, when it is coupled with calcium, the resulting crystal formations can collect in your cartilage and lead to a form of arthritis called calcium pyrophosphate dihydrate deposition disease (CPPD)—also known as pseudogout.
Synovial fluid analysis - UpToDate
2024年9月17日 · Synovial fluid analysis is helpful for determining the underlying cause of arthritis, particularly for septic or crystal-induced arthritis. The white cell count, differential count, cultures, Gram stain, and crystal search using polarized light microscopy are the most useful studies.
Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD …
Synovial fluid analysis is the gold standard for diagnosis and assists in excluding acute CPP arthritis and septic arthritis, although the two can occasionally co-exist. Classic synovial fluid findings include rhomboid-shaped crystals that exhibit weakly positive birefringence or no birefringence under polarised light microscopy (PLM).
Identification of crystals in synovial fluid | Annals of the …
Synovial fluids can contain a number of crystals and other particulate matter. Some of these, particularly monosodium urate monohydrate (MSUM) and calcium pyrophosphate dihydrate (CPPD) crystals, are pathogenic; others, including cholesterol and other lipid particles and the basic calcium phosphates (BCPs), including apatites, are of doubtful ...
Calcium Pyrophosphate Arthritis - Calcium Pyrophosphate Arthritis ...
Diagnosis of CPP arthritis is established by identifying rhomboid- or rod-shaped crystals in synovial fluid that are not birefringent or are weakly positively birefringent on polarized light microscopy. Joint fluid in acute flares has findings typical of inflammation; thus, coincident infectious arthritis and gout (other common causes of ...
Calcium Pyrophosphate Deposition Disease | NEJM - New …
2016年6月30日 · CPPD disease is most accurately diagnosed by the finding of positively birefringent, rhomboid-shaped crystals in synovial fluid from the affected joint .
Calcium pyrophosphate deposition - BMJ Best Practice
2024年2月15日 · Calcium pyrophosphate arthritis is caused by deposition of calcium pyrophosphate (CPP) crystals. It can be difficult to diagnose as CPP crystals in synovial fluid can be small, sparse, and difficult to find. In patients <60 years of age, underlying metabolic conditions associated with calcium pyr...