GP1BA - Wikipedia
Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (C luster of D ifferentiation 42b), is a protein that in humans is encoded by the GP1BA gene.
Understanding platelet generation from megakaryocytes: …
2016年3月10日 · The GPIbα (CD42b) subunit of the von Willebrand factor GPIb-V-IX receptor complex functions in cellular adhesion 46,47 and GPVI is one of the collagen receptors involved in signaling. 48 The cleavage of the N-terminal domain of GPIbα (termed glycocalicin 49 ), which occurs during platelet storage, was identified on mouse platelets that were ...
Anti-CD42b Antibodies | Invitrogen - Thermo Fisher Scientific
Find the CD42b antibody that fits your needs. Choose from 1 of 51 CD42b antibodies, which have been validated in experiments with 70 publications and 94 images featured in our data gallery. Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications.
Role of platelet function and platelet membrane glycoproteins in ...
2016年7月11日 · CD42b (GPIb) is an important platelet adhesion receptor that promotes platelet to secret platelet-derived growth factors and 5-HT, accelerating the deformation and aggregation of platelets. GpIIb/IIIa complex is the most abundant membrane glycoprotein and can mediate the binding of platelet and fibrinogen (Fg), which is the final pathway of ...
Mechanisms of platelet clearance and translation to improve …
2018年4月5日 · It is also noteworthy that CCCP treatment induces modest PS exposure but significant ectodomain shedding of glycoprotein Ibα (GPIbα; CD42b) in platelets. 31 These results link the mitochondrial damage to accelerated platelet clearance and, as described in “GPIb-IX signaling: a trigger for platelet clearance,” implicate the shedding of ...
A guide to molecular and functional investigations of platelets to ...
2022年3月3日 · The procoagulant microvesicles (phosphatidylserine + CD41 + CD42b +) released by activated platelets in circulation bearing receptors for collagen and VWF contribute to hemostasis and thrombosis...
Platelet GPIbα is a mediator and potential interventional target for ...
2019年4月1日 · For quantification of platelet staining on human (CD61) and mouse (CD42b) tissue, software-based analysis and counting at the screen (CD42b; 100 high-power fields; 40×) were performed.
The platelet storage lesion, what are we working for? - PMC
Shedding of CD42b (GPIbα) may be associated with decreased surface exposure and attenuate platelet response to ristocetin, 30 and it may cause decreased capability of platelet adhesion at high shear or premature platelet clearance.
Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy …
2018年7月9日 · Platelet surface CD42a and CD42b showed a trend to be dose-dependently decreased with TRAP stimulation.
JCI - Platelets mediate inflammatory monocyte activation by …
2021年12月29日 · Here, we showed that the SARS-CoV-2 spike protein engaged the CD42b receptor to activate platelets via 2 distinct signaling pathways and promoted platelet-monocyte communication through the engagement of P selectin/PGSL-1 and CD40L/CD40, which led to proinflammatory cytokine production by monocytes.