Integrin alpha M - Wikipedia
CD11b, as an integrin molecule on the surface of leukocytes, plays an important role in cell migration, adhesion, and transmigration across blood vessels, because it can bind to components of extracellular matrix and intracellular adhesion molecules (ICAMs) on the endothelial surface.
CD11b Antigen - an overview | ScienceDirect Topics
CD11b Antigen. Macrophage antigen-1 (Mac-1, CD11b/CD18, CR3) is an important member of the β2-integrin subunit, which is widely expressed on the surface of leukocytes (including neutrophils and monocytes) and affects leukocyte migration and tissue infiltration.
CD11b Marker for Macrophages and Microglia - Bio-Techne
CD11b is a protein on immune cells like macrophages and microglia, aiding in cell adhesion, migration, and immune response. It’s used in immune and neuro research.
CD11b immunophenotyping identifies inflammatory profiles in …
2015年9月30日 · CD11b high AMΦs correlated with increased lung monocyte influx and respiratory failure severity in a 21-day follow-up of ARDS patients requiring mechanical ventilation. 45 AMΦ CD11b...
Macrophage-1 antigen - Wikipedia
Macrophage-1 antigen (hereafter complement receptor 3 or CR3) (CD11b/CD18) is a human cell surface receptor found on B and T lymphocytes, polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages.
ITGAM Gene - GeneCards | ITAM Protein | ITAM Antibody
2024年10月2日 · ITGAM (Integrin Subunit Alpha M) is a Protein Coding gene. Diseases associated with ITGAM include Systemic Lupus Erythematosus 6 and Neutropenia, Severe Congenital, X-Linked. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.
Integrin CD11b activation drives anti-tumor innate immunity
2018年12月19日 · CD11b activation promotes pro-inflammatory macrophage polarization by stimulating expression of microRNA Let7a. In contrast, inhibition of CD11b prevents Let7a expression and induces cMyc...
CD11b is a therapy resistance– and minimal residual …
2010年5月6日 · A consistently increased mRNA expression of the adhesion receptor CD11b is a hallmark of the reported genomewide gene expression changes in precursor B-cell acute lymphoblastic leukemia (PBC-ALL) after 1 week of induction therapy.
Small Molecule–Mediated Activation of the Integrin CD11b
The integrin CD11b/CD18 (also known as Mac-1), which is a heterodimer of the αM (CD11b) and β2 (CD18) subunits, is critical for leukocyte adhesion and migration and for immune functions. Blocking i...
Small Molecule–Mediated Activation of the Integrin CD11b/CD18 …
2011年9月6日 · CD11b/CD18 is normally present in an inactive conformation in circulating leukocytes, but it is rapidly activated (4 - 6) to mediate leukocyte adhesion, migration, and accumulation at the sites of inflammation.