Physiology, Bile Secretion - StatPearls - NCBI Bookshelf
2022年9月26日 · The main steps in the formation of bile are the uptake of bile acids and ions from plasma across the basolateral (sinusoidal) membrane, transport through the hepatocyte, and excretion via the canalicular membrane.
Physiology, Bile - StatPearls - NCBI Bookshelf
2022年9月12日 · The GI system is responsible for regulating the alkaline secretions of bile, secreting CCK which causes contraction of the gallbladder, active absorption of bile salts in the terminal ileum, excretion of cholesterol, and excretion of bilirubin in the form of stercobilin.
Bile Formation and Secretion - PMC - PubMed Central (PMC)
Bile is a complex aqueous secretion that originates from hepatocytes and is modified distally by absorptive and secretory transport systems in the bile duct epithelium. Bile then enters the gallbladder where it is concentrated or is delivered directly to the intestinal lumen.
Biliary Excretion - an overview | ScienceDirect Topics
Biliary excretion provides a back-up pathway when renal function is impaired. The reabsorption of drugs excreted in the bile can lead to an enterohepatic cycle, which can prolong their action (e.g. some benzodiazepines).
Biliary secretion and excretion in health and disease: Current concepts ...
2007年1月1日 · A synthetic bile acid, norUDCA is absorbed by the biliary ductules after secretion and cures the peribiliary fibrosis occurring in the MDR2 -/- mouse which lacks biliary phospholipid. In this brief review, emphasis will be on current concepts of biliary secretion and excretion as perceived by the author.
Biliary Excretion - an overview | ScienceDirect Topics
Biliary excretion is one of the primary elimination routes for xenobiotics and the conjugate metabolites (Arias et al., 1993). Biliary excretion requires active secretory transport because drugs are transported across the biliary epithelium against a concentration gradient.
Biliary Drug Excretion - SpringerLink
2021年8月4日 · Biliary excretion refers to the elimination of endogenous and exogenous compounds (and their metabolites) predominantly by secretion through the canalicular membrane into the canaliculus, a space formed between the apical membranes of neighboring hepatocytes.
Role of bile acids and their receptors in gastrointestinal and …
2022年2月14日 · BAs are secreted into the bile mainly as taurine or glycine conjugates, which are negatively charged molecules requiring specific transport systems allowing their efficient uptake and excretion...
Bile acid metabolism and signaling in health and disease: …
2024年4月26日 · Using this mechanistic model of bile acids, we explain how abnormal bile acid physiology drives disease pathogenesis, emphasizing how ceramide synthesis may serve as a unifying pathogenic...
Bile Acids and Metabolic Regulation - PubMed Central (PMC)
TRADITIONAL ROLE OF BILE ACIDS: DIGESTION, EXCRETION, AND AUTOREGULATION. Bile acids are potent “digestive surfactants” that promote absorption of lipids (including fat-soluble vitamins), acting as emulsifiers (1,2). Bile acids represent the primary pathway for cholesterol catabolism and account for ∼50% of the daily turnover of cholesterol .