AKT1 - Wikipedia
AKT1. RAC (Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. [5] It is commonly referred to as PKB, or by both names as "Akt/PKB".
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AKT1 gene - MedlinePlus
The AKT1 gene provides instructions for making a protein called AKT1 kinase. This protein is found in various cell types throughout the body, where it plays a critical role in many signaling pathways.
AKT1 AKT serine/threonine kinase 1 [ (human)] - National Center …
2024年11月3日 · Akt1 is involved in HCV release by promoting endoplasmic reticulum-to-endosome transition of infectious virions. IRS1 promotes thyroid cancer metastasis through EMT and PI3K/AKT pathways.
AKT1 Gene - GeneCards | AKT1 Protein | AKT1 Antibody
2024年10月1日 · AKT1, also referred to as protein kinase B, is a known oncogene. AKT activation relies on the PI3K pathway, and is recognized as a critical node in the pathway. The E17 hotspot is the most characterized of AKT1 mutations, and has been shown to …
Defining the Akt1 interactome and its role in regulating the
2018年1月22日 · Akt1, a serine/threonine kinase, is a multi-functional protein implicated in regulation of cell growth, survival and proliferation. Though it has a role in G1/S progression, the manner by...
AKT1 AKT serine/threonine kinase 1 [ Homo sapiens (human) ]
2020年6月28日 · The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery.
AKT Kinase Pathway: A Leading Target in Cancer Research
AKT1, a serine/threonine-protein kinase also known as AKT kinase, is involved in the regulation of various signalling downstream pathways including metabolism, cell proliferation, survival, growth, and angiogenesis.
UniProt
2005年2月1日 · AKT1 is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner.
Akt1 regulates pathological angiogenesis, vascular maturation …
2005年10月16日 · Here we show that Akt1 is the predominant isoform in vascular cells and describe the unexpected consequences of Akt1 knockout on vascular integrity and pathological angiogenesis.