associated with succinate dehydrogenase deficiency, impairs the activity of the ubiquitin-conjugating enzyme UBC12 leading to tumor-promoting protein accumulation and drug resistance in AML.

With TYMIRIUM technology being an succinate dehydrogenase inhibitors (SDHI) it will provide protection against all major plant parasitic nematodes — such as soybean cyst, root knot, reniform, lesion, ...

If you want to sleep better, this is what you need to know about doxylamine. Doxylamine succinate is an antihistamine medication often used to treat allergies and the common cold. That is because ...

More information: Shane M. O'Carroll et al, Itaconate drives mtRNA-mediated type I interferon production through inhibition ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Triple-negative breast cancer (TNBC) ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Macrophages fight infection and ensure tissue ...

Department of Microbiology & Cell Biology, Indian Institute of Science, India Centre of Infectious Disease Research, Indian Institute of Science, Bangalore, India Pharmacology Division, CSIR-Central ...

Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone ...

Objective The objectives of this study were to compare the clinical features of patients with SLE with and without myopathy and to describe the muscle biopsy features of patients with SLE myopathy.

Despite extensive efforts in drug development for cancer treatment, only a few successful therapeutic agents and strategies have emerged that specifically target patients with metastatic cancer, ...

Fungicides remain effective against crop diseases but some products are starting to show reduced sensitivity to powdery mildew, septoria and net blotch in cereals.