Widespread alterations in RNA processing (splicing, polyadenylation, decay, etc.) are common in dynamic cell states during development and malignancy. For example, many cancers harbor elevated levels ...

Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have made a major discovery in how human ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

Alternative pathways of RNA processing are regulated in response to signaling cues often coordinating expression of gene networks in response to physiological change including in development and ...

Results of a multinational genetic study suggest that defects in transfer RNA (tRNA) processing may be responsible for many cases of the neurodegenerative disease pontocerebellar hypoplasia (PCH).

The idea that speckles might be storage sites for spliceosomes triggered Guttman to look deeper into how nuclear organization ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Altered RNA processing — a consequence of high levels of RTP801 — is highly detrimental to neurons, disrupting their ability to synthesize proteins and respond to stress.

RNA quality control is the active process by which ribonucleic acid (RNA) molecules are monitored for integrity. The RNA quality control machinery directs the degradation of compromised RNA molecules.

Altered RNA processing—a consequence of high levels of RTP801—is highly detrimental to neurons, disrupting their ability to synthesize proteins and respond to stress.

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors ...

While we’ve mapped the RNA-binding sites for a number of C2H2 zinc finger proteins, we’re just starting to scratch the surface of investigating their functions.” ...