They play a vital role in the trafficking of innate immune system cells, platelets and T lymphocytes. Three groups of selectins exist: E-selectin (CD62E), P-selectin (CD62P) and L-selectin (CD62L).

Hyperactivated platelets overexpress P-selectin and the cluster of differentiation 40 ligands (CD40L) while underexpressing prostaglandin E1 and endothelial nitric oxide synthases (peNOS ...