De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...

The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous with one another. Therefore, the membrane lipids and proteins that are synthesized in ...

Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...

In a breakthrough that could eventually lead to new treatments for devastating conditions like Alzheimer’s disease, ...

Think back to that basic biology class you took in high school. You probably learned about organelles, those little "organs" ...

Stress granules (SGs) form in response to diverse environmental signals. Here, the signaling pathways that connect lysosomal ...

It did this by causing the lysosomes—the 'cell's incinerators'—to move to the surface of the cell, where they fused with the ...

More information: Shubham Singh et al, PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in ...

In most cells, lysosomes typically cluster around the nucleus. But in pancreatic cancer cells, the researchers found that INPP4B drove the lysosomes from the cell interior to the periphery ...

In a paper published in National Science Review, a collaborative team of scientists report the development of a ...

1) and uncovering its regulation and effects on cell populations. By entosis, cells utilize the machinery of cell adhesion, autophagy, and lysosomes to engulf and kill their live neighbors, in a ...