By analyzing proteomes and transcriptomes across tissues like the brain, heart, and skin, they uncovered proteins linked to ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...

This review discussed experimental mouse models used in the pre-clinical study of liver fibrosis regression, a pivotal ...

Physiological extracellular matrix (ECM) calcification or mineralization ... may yet be found and could act in tissues such as skin, liver and lung. It is conceivable that the absence of ECM ...

They did so by analyzing the proteomes and transcriptomes of brain, artery, heart, kidney, liver, lung, skeletal muscle, and ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

This results in progressive liver disease secondary to AAT polymerization ... Canonical pathways related to fibrosis, ...