Thus, neuronal insulin-like signaling appears to be a key regulator of various essential functions in C. elegans, and the metabolic and reproductive defects induced by whole-body deletion of DAF-2 ...

Additionally, chronic endoplasmic reticulum (ER) stress and inflammation from high-fat diets further disrupt leptin signaling ...

One possibility is that in an attempt to overcome the inhibition within the metabolic insulin-signaling pathway, hyperinsulinemia may continue to stimulate the mitogenic insulin-signaling pathway ...

the PI3K–PKB/Akt pathway, which is responsible for most of the metabolic actions of insulin, including uptake of glucose by the glucose transporter GLUT4 and glycogen synthesis; and second ...

A fat-derived protein known for its effects on the liver and skeletal muscle might also serve as an energy-conserving signal to the ... the body’s response to insulin. Studies have also ...

"We know that reducing insulin, and reducing IGF signaling, slows aging and extends lifespan in flies," Tatar said. Tatar ...

Hypoglycemia is an extremely common side effect of insulin therapy experienced mainly by patients with type 1 diabetes ...

The discovery of a gut-to-brain regulation pathway in flies calls for ... "We know that reducing insulin, and reducing IGF signaling, slows aging and extends lifespan in flies," Tatar said.

The discovery of a gut-to-brain regulation pathway in flies calls for ... “We know that reducing insulin, and reducing IGF signaling, slows aging and extends lifespan in flies,” Tatar said.