After exposure to trans-retinoic acid, these cells can develop into two distinct forms of extra-embryonic endoderm. To date, differential library screening has been the best tool available to ...

Each of these paracrine interactions requires cell-specific receptors on adjacent cells derived from the mesoderm or endoderm, respectively, to serially up-regulate the signaling pathways between ...

Human induced pluripotent stem cells (iPSCs) have a great potential for scientific and medical applications. They are used in ...

We are interested in how cells become specialized, and how they collaborate at the population level to collectively build organs. Our focus is on the endoderm, the progenitor tissue that gives rise to ...

To treat his impaired islet cell function, the research team generated functional islet-like clusters, called “E-islets,” ...